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Solvinal "Effervescent Granules"

To the Medical and Pharmaceutical Professions


Each 5 gm contains:  
Colchicine 0.3 mg
Piperazine hydrate 0.128 gm
Atropine sulphate 0.128 mg

Pharmacological Properties:
Solvinal effervescent granules is an effective drug combination which contains colchicine that reduces lactic acid production by leukocytes resulting in a decrease in uric acid deposition, also it has an anti-inflammatory action. Piperazine is an excellent solvent for uric acid.
Atropine sulphate acts peripherally as a competitive antagonist of the muscarinic receptors of acetyl choline so it inhibits contractions of the ureter and bladder.

Solvinal is indicated in treatment of:
•    Acute and chronic gout.
•    Acute gouty arthritis.
•    Gout prophylaxis.
•    Ureteral and biliary colic.

Solvinal is contraindicated in patients with:
- Hypersensitivity to any of the components of the drug.
- Glaucoma and asthma.
- Combined renal and hepatic disease or cardiac disorders.

•    Chronic treatment with Solvinal can cause blurred vision.
•    Patients with prostatism can have difficulty in urination with the use of Solvinal.

Solvinal is not to be used in pregnancy.

Caution should be exercised when solvinal is administered to a nursing woman.

Drug interactions:
- The potential of Solvinal to cause mouth dryness may be increased if it is given with tricyclic antidepressants, antipsychotics and antiparkinsonism drugs.

Side effects:
•    Slight dryness of nose and mouth.
•    Bradycardia.
•    Nausea, vomiting, diarrhea with abdominal pain.
•    Peripheral nerve inflammation, myopathy, and bone marrow depression have been reported with long-term administration.

Signs of overdosage include nausea, vomiting, diarrhea, abdominal pain, tachycardia and mydriasis.
Treatment: Following gastric lavage, administration of a saline purgative and oxygen respiration.

Dosage and Administration:
Unless otherwise prescribed by the physician, the content of one sachet is dissolved in half a glass of water before meals and taken 3 times daily.

Therapeutic category: Antigout agent

Legal category: Prescription only medicine (POM).

Store in a dry cool place, below 25º C, protect from light.

Box containing 10 sachets, 5 gm each.

Medicament is a product, which affects your health and its consumption contrary to instructions is dangerous for you. Follow strictly the doctor’s prescription, the method of use and the instructions of the pharmacist who sold the medicament.
- The doctor and the pharmacist are the experts in medicines, their benefits and risks.
- Do not by yourself interrupt the period of treatment prescribed.
- Do not repeat the same prescription without consulting your doctor.
- Keep all medicaments out of reach of children.

Council of Arab Health Ministers, Union of Arab Pharmacists.