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 To the medical and pharmaceutical professions.


Each ampoule of 5 ml contains:                                    
Ascorbic acid (Vitamin C)                 500 or 1000 mg
Pharmacological properties:
Vitamin C is an essential coenzyme for collagen formation, tissue repair and synthesis of lipids and proteins. It acts both as reducing agent and as antioxidant. It is necessary for many physiological functions such as metabolism of iron, carbohydrates, tyrosine and folic acid as well as resistance to infection, cellular respiration, and preservation of blood vessel integrity. Signs of early vitamin C deficiency include malaise, irritability, hyperkeratosis of hair follicles and bleeding from the nose.

Vitamin C is normally present in both plasma and red blood cells. The absorbed vitamin is well distributed in all body tissues. Vitamin C is excreted by the kidney.

Cevarol ampoules are indicated in the following cases:-
-    Prevention and treatment of scurvy.
-    Faulty bone, tooth development, bleeding gums and loosened teeth.
-    Patients receiving total parentral nutrition.
-    Cases of increased requirements of vitamin C such as tuberculosis, hyperthyroidism, peptic ulcer, neoplastic disease, stress, pregnancy, lactation, burns, delayed fracture and wound healing.
-    Febrile states, chronic illness, and infection (pneumonia, whooping cough, diphtheria, sinusitis, and rheumatic fever).
-    Prevention of common cold or shortening its duration.  

Cevarol ampoules are contraindicated in persons who have shown hypersensitivity to any component of the preparation.

- Persons with diabetes, those on sodium-restricted diets or anticoagulant therapy should not take excessive doses of vitamin C.

- Cevarol ampoules containing sulphites may cause allergic-type reactions including anaphylactic symptoms in certain susceptible people.

Too rapid intravenous injection is to be avoided.

Cevarol ampoules should be given to a pregnant woman only if clearly needed.

Caution should be exercised when Cevarol ampoules are administered to a nursing woman.

Drug interactions:
-    Acidification of the urine by Cevarol ampoules may cause precipitation of cystine, urate or oxalate stones and will alter the excretion of certain other drugs administered concurrently.
-    Concurrent administration of Cevarol will interfere with the effectiveness of disulfiram given to patients to encourage abstention from alcohol.

Side effects:
-    Transient mild soreness or pain and swelling may occur at the site of intramuscular or subcutaneous injection.
-    Large doses may cause diarrhea.

Dosage and administration:
-    The average protective dose of vitamin C for adults is 70 to 150 mg daily.
-    In the presence of scurvy, doses of 300 mg to 1g daily are recommended.
-    The usual therapeutic parenteral dose ranges from 100 to 250 mg once or twice daily.
-    If the deficiency is extreme, 1 to 2 g may be given.
-    To enhance wound healing, doses of 300 to 500 mg daily for a week or 10 days both preoperatively and postoperatively are generally considered adequate.
-    Doses of 1 gm daily for 4 to 7 days may be given before operation in gastrectomy patients.
-    For severe or deep and extensive burns, daily doses of 200 to 500 mg up to 1 to 2 gm are recommended.

Therapeutic category: Vitamins.

Legal category: Prescription only medicine (POM).

Store at a temperature below 30° C, protect from light.

Boxes of 6 ampoules 500 mg.
Boxes of 3 ampoules 1000 mg.

Medicament is a product, which affects your health and its consumption contrary to instructions is dangerous for you. Follow strictly the doctor’s prescription, the method of use and the instructions of the pharmacist who sold the medicament.
- The doctor and the pharmacist are the experts in medicines, their benefits and risks.
- Do not by yourself interrupt the period of treatment prescribed.
- Do not repeat the same prescription without consulting your doctor.
- Keep all medicaments out of reach of children.

Council of Arab Health Ministers, Union of Arab Pharmacists.