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Varolex B12 vial and ampoule


Composition:

Each vial 9 ml contains:
Thiamine HCl 1 gm
Riboflavine (Equivalent to 27.33 mg Riboflavine 5 phosphate sodium) 20 mg
Pyridoxine HCl 50 mg
Calcium pantothenate 50 mg
Nicotinamide 0.5 mg

Each ampoule contains: Cyanocobalamin 1 mg

Properties:
In the body, Thiamine HCl combines with adenosine triphosphate to from thiamine pyrophosphate, which acts as a co-enzyme in the decarboxylation of ketoacids.

Riboflavin is required for tissue respiration and indirectly involved in maintaining erythrocyte integrity.
Pyridoxine is essential for the metabolism of certain aminoacids, carbohydrates and lipids and the synthesis of some neurotransmitters.
Nicotinamide is essential for glycogenolysis, tissue respiration and lipid metabolism.
Calcium pantothenate is a precursor of coenzyme A and is essential for acetylation reactions.
Cyanocobalamin is required for nucleoprotein and myelin synthesis, cell production, normal growth, and for the maintenance of normal erythropoiesis.

Indications and usage:
Varolex B12 vial is indicated in:
Vitamin deficiency. 
Prophylaxis and treatment of Wernicke korsakoff syndrome in IM rout only, in patients with CV disease of nutritional origin.
Treatment of pernicious anemia, beri-beri.
 
Contraindications:
Varolex is contraindicated in: patients with hypersensitivity to any of the components of the product.
Patients with active liver disease, peptic ulcer disease, hyperuricemia with a history of gouty arthritis, uncontrolled hyperglycemia or severe hypotension.

Side effects:
Some of the following side effects may occur in some cases:
Nausea, urticaria, sweating, restlessness, headache, diarrhea, abnormal liver function, flushing.

Drug interactions:
- Postural hypotension may occur when varolex is administered with vasoactive drugs or ganglionic blocking agents.
- Because nicotinamide can cause hyperglycemia dosage adjustment of insulin or oral antihyperglycemic therapy may be required in diabetic patients.  

Warnings & Precautions:
-  Periodic monitoring of blood glucose concentration during Varolex therapy is advised especially in the early phase of treatment.    
-  Patients with gall bladder disease, history of jaundice or liver disease should be monitored closely while on Varolex.
-  Use of varolex should be avoided in patients with early leber's disease (hereditary optic nerve atrophy).

Pregnancy & lactation:
No adverse effects are reported with intake of normal daily requirements.

Dosage and administration:
One ml of the mixed solution is injected intramuscularly daily.  

Therapeutic category: Multivitamins.

Legal category:
OTC.
 
Package:

Storage:

 

THIS IS A MEDICAMENT
Medicament is a product, which affects your health and its consumption contrary to instructions is dangerous for you. Follow strictly the doctor’s prescription, the method of use and the instructions of the pharmacist who sold the medicament.
- The doctor and the pharmacist are the experts in medicines, their benefits and risks.
- Do not by yourself interrupt the period of treatment prescribed.
- Do not repeat the same prescription without consulting your doctor.
- Keep all medicaments out of reach of children.

Council of Arab Health Ministers, Union of Arab Pharmacists.