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Indacin Suppositories


Each suppository contains:-    
Indomethacin                           100 mg

Indomethacin is a nonsteroidal anti-inflammatory drug with prominent anti-inflammatory activity in addition to analgesic and antipyretic effects. Indomethacin is one of the most potent inhibitors of the enzyme cyclooxygenase and so causes a marked reduction in prostaglandin synthesis.
The analgesic effect of indomethacin results from both peripheral and central effects. It also inhibits the motility of polymorphonuclear leukocytes. Indomethacin depresses the synthesis of mucopolysaccharides and uncouples oxidative phosphorylation.

Indomethacin is well absorbed after rectal administration. The overall bioavailability after rectal administration is 80%. Indomethacin is 90–94% protein bound and is extensively metabolized in the liver. The major route of elimination is in urine.

Indications & usage:-
Indacin suppositories are indicated in the following cases:
1-    Rheumatoid arthritis.
2-    Osteoarthritis.
3-    Ankylosing spondylitis
4-    Acute gouty arthritis.
5-    Dysmenorrhea.
6-    Painful conditions caused by inflammation such as:
         i.   Bursitis
         ii.  Tendinitis
         iii. Pleurisy
         iv. Traumatic synovitis
7-    Prophylaxis and treatment of vascular headache.

Indacin shouldn’t be used in:
Pregnant women, nursing mothers, infants, children up to 14 years old, patients who are hypersensitive to this product, patients with a history of proctitis or recent rectal bleeding.
Indomethacin should not be given to patients with active peptic ulceration, while it is preferable to avoid them in patients with current or previous gastrointestinal ulceration or bleeding, and to withdraw them if gastrointestinal lesions develop.

Side Effect:-
Gastrointestinal disturbances, headache, dizziness and gastric ulcer. Rarely, confusion and thrombocytopenia may occur.

Drug Interactions:
1- Anticoagulants:
    Bleeding that may occasionally occur from peptic ulcer induced by indomethacin will be more severe if the patient is receiving anticoagulant.
2- Potassium sparing diuretics:-
    Concurrent use with indomethacin may cause hyperkalemia.

Dosage and Administration:-
 1-2 suppositories daily or as directed by the physician.

Box contains 10 suppositories.