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Broncholase Syrup

Composition:-
Each 15 ml conatins:
Ammonium chloride                0.5 gm
Tincture Ipecacuanha             0.5 ml
Chlorpheniramine maleate     0.0025 gm

Pharmacological properties:-
Broncholase ayrup is specifically formulated to contain two expectorants that increase the volume of secretions in the respiratory tract to facilitate their removal by ciliary action & coughing. This is achieved by a reflex irritant effect on the gastric mucosa. Chlorpheniramine maleate in Broncholase syrup blocks competitively the effects of histamine on H1 receptors & prevents the constrictor responses to histamine of bronchial smooth muscles. It reduces various allergic symptoms.

Pharmacokinetics:-
Broncholase syrup is rapidly absorbed from the gastrointestinal tract.
Ammonium ion of ammonium chloride is converted into Urea in the liver, the anion thus liberated into the blood stream & extracellular fluid decreases the pH of urine and causes metabolic acidosis. Chlorpheniramine maleate is bound (about 70%) to plasma proteins and is excreted in the urine.

Indications:-
For the management of productive cough with allergic symptoms.

Contraindications:-
Ammonium salts are contraindicated in the presence of impaired hepatic or renal functions. Ipecacuanha should not be given to patients at risk of seizures.

Warnings:-
Broncholase syrup containing chlorpheniramine maleate should be used with caution in prostatic hypertrophy, urinary retention, glaucoma, cardiovascular diseases, pyloroduodenal obstruction, hepatic disease and dose reduction may be necessary in renal impairment.
Caution may be required in epilepsy.
Not to be used for uncontroled diabeties mellitus.
Children and elderly are more susceptible to side effects.
It is not recommended for use in neonates.

Precautions:-
Pregnancy: the safety of chlorpheniramine in pregnancy has not been established.
Lactation: chlorpheniramine is excreted in small amounts in breast milk & mothers taking the drug should not breast–feed.

Adverse effects:-
Ammonium salts & Ipecacuanha are irritant to the gastric mucosa & may produce nausea and vomiting particularly in large doses. Chlorpheniramine maleate causes dryness of mouth & throat, dizziness, anorexia and fatigue.

Drug interactions:-
MAO inhibitors & tricyclic antidepressants increase its sedative & anticholinergic effects.
Concomitant administration of milk impairs the efficacy of Ipecacuanha.
Additive CNS depression may occur when antihistamines (e.g. Chlorpheniramine maleate) are administered concomitantly with alcohol.  

Overdosage:- Unconsciousness, hypotension and coma.
Antidote:- Activated charcoal is given to delay absorption followed, if necessary, by gastric lavage.

Dosage & Administration:-
Adults: one teaspoonful 3 to 4 times daily.
Children: ½ to 1 teaspoonful daily.

Therapeutic category:- Expectorant.

Legal category:- Prescription only medicine.

Storage conditions:
Protect from light at a temperature below 30° C.

Pack size:- Bottles of 120 ml each.

THIS IS A MEDICAMENT
Medicament is a product, which affects your health and its consumption contrary to instructions is dangerous for you.Follow strictly the doctor’s prescription, the method of use and the instructions of the pharmacist who sold the medicament.
- The doctor and the pharmacist are the experts in medicines, their benefits and risks.
- Do not by yourself interrupt the period of treatment prescribed.
- Do not repeat the same prescription without consulting your doctor.
- Keep all medicaments out of reach of children.

Council of Arab Health Ministers, Union of Arab Pharmacists.