Vermin

Composition:
Each tablet contains:
Mebendazole          100 mg

Pharmacological properties:
Mebendazole is a synthetic broad-spectrum anthelmintic it inhibits the formation of the worm´s microtubules and causes depletion of glucose in the worm.
Mebendazole does not appear to affect blood glucose concentration in the host.

Pharmacokinetics:
Mebendazole is absorbed poorly after oral administration. The plasma half–life ranges from 2.8 – 9 hours. Plasma protein binding is 95%. In man, approximately 2% of the administered dose is excreted in urine and the remainder in feces as unchanged drug or primary metabolite.

Indications:
Mebendazole is indicated for the treatment of Enterobius Vermicularis (Pin worm), Trichuris trichiura (Whip worm), Ascaris lumbricoides (Common round worm), Ancylostoma duodenale (Common hook worm), Necator americanus (American hook worm) in single or mixed infections.

Contraindications:
Mebendazole is contraindicated in persons who have shown hypersensitivity to the drug.

Precautions:
General:
Periodic assessment of organ system functions including hematopoietic and hepatic, is advisable during prolonged therapy.

Pregnancy:
Mebendazole should be used only if the potential benefit justifies the potential risk to the fetus (especially during the first trimester).

Lactation:
Caution should be exercised when Mebendazole is administered to a nursing woman.

Drug interactions:
Cimetidine inhibits Mebendazole metabolism & may result in an increase in plasma concentrations of Mebendazole.

Warnings:

There have been rare reports of neutropenia and agranulocytosis when vermin was taken for prolonged periods and at dosage above those recommended.

Side effects:

•    Gastrointestinal: Transient symptoms of abdominal pain and diarrhea have occurred in cases of massive infection and expulsion of worms.
•    Hypersensitivity: Rash, urticaria and angioedema have been observed on rare occasions.
•    Central nervous system: very rare cases of convulsion have been reported.
•    Liver: hepatitis when taken for prolonged periods and at dosage above those recommended.


Overdosage:
In the event of accidental overdosage gastrointestinal complaints lasting up to a few hours may occur. Vomiting & purging should be induced. Activated charcoal may be given.

Dosage and Administration:
The same dosage schedule applies to children & adults.

  Pin worm
(enterobiasis)
Whip worm
(trichuriasis)
Common Round worm
(ascariasis)
Hook worm
Mebendazole Dose 100 mg once only 100 mg morning & evening for 3 consecutive days 100 mg morning & evening for 3 consecutive days  100 mg morning & evening for 3 consecutive days

If the patient is not cured three weeks after treatment, a second course of treatment is advised.

Therapeutic category: Anthelmintic.

Legal category: POM.

Storage: Store in a dry place at a temperature below 30º C.

Package: Box containing 6 tablets.
 

THIS IS A MEDICAMENT
Medicament is a product, which affects your health and its consumption contrary to instructions is dangerous for you. Follow strictly the doctor’s prescription, the method of use and the instructions of the pharmacist who sold the medicament.
- The doctor and the pharmacist are the experts in medicines, their benefits and risks.
- Do not by yourself interrupt the period of treatment prescribed.
- Do not repeat the same prescription without consulting your doctor.
- Keep all medicaments out of reach of children.

Council of Arab Health Ministers, Union of Arab Pharmacists.