Hydrex

Composition:-
Each tablet contains:
Hydrochlorothiazide           25 mg

Pharmacological Actions:-
Hydrochlorothiazide is a diuretic and antihypertensive agent. It affects the distal renal tubular mechanism of electrolyte reabsorption.

Pharmacokinetics:-
Hydrochlorothiazide is not metabolized but is eliminated rapidly by the kidney.
At least 61% of the oral dose is eliminated unchanged within 24 hours.
Hydrochlorothiazide crosses the placental but not the blood–brain barrier and is excreted in breast milk.
Indications:-
Hydrex is indicated as adjunctive therapy in edema associated with congestive heart failure, hepatic cirrhosis, and corticosteroid and estrogen therapy.
It is indicated in the management of hypertension either as the sole therapeutic agent or to enhance the effectiveness of other antihypertensive drugs.

Contraindications:
Anuria, hypersensitivity to hydrochlorothiazide or to other sulfonamide derived drugs.

Warnings:
Use with caution in sever renal disease and in patients with impaired hepatic function. Hypokalemia may be avoided or treated by use of potassium sparing diuretics or potassium supplements such as foods with a high potassium content.


Side Effects:-
All patients receiving diuretic therapy should be observed for evidence of fluid or electrolyte imbalance namely, hyponatremia and hypokalemia.

Warning signs of fluid and electrolyte impalance include weakness, hypotension, diarrhea, nausea, cramping, anemia and renal dysfunction.

Drug interactions:-
Barbiturates, antidiabetic drugs, certain antihypertensives as well as, corticosteroids may interact with thiazide diuretics.

Dosage and Administration:-

Adults:-
For Edema:-
25–100 mg daily as a single or divided dose. Many patients with edema respond to intermittent therapy (administration on alternate days).

For Control of Hypertension:
25 mg daily as a single dose. The dose may be increased to 50 mg daily given as a single or two divided doses.

Infants and Children:
For diuresis and for control of hypertension: 1 to 2 mg/kg per day in single or two divided doses, not to exceed 37.5 mg per day in infants up to 2 years of age or 100 mg per day in children 2 to 12 years of age.
In infants less than 6 months of age, doses up to 3 mg/kg per day in two divided doses may be required.

Use in pregnancy
Routine use of diuretics during normal pregnancy is inappropriate and exposes mother and fetus to unnecessary hazards.
Diuretics do not prevent development of toxemia of pregnancy and there is no satisfactory evidence that they are useful in the treatment of toxemia

Package:-
Boxes of 30 tablets.