Active Ingredient: Atropine sulphate Company: Memphis for Pharmaceutical & Chemical Industries. Qualitative and quantitative composition Each 1 ml ampoule contains: Active ingredient: atropine sulphate 1 mg Excipients: Sodium chloride for injection, water for injection. Pharmaceutical form Solution for I.M., I.V. or S.C. injection. Clear, Colourless Solution free from visible particulate matter. Clinical particulars Therapeutic indications Atropine Sulfate Injection 0.1 % injection USP 2022 is used: • As a preoperative medication for the reduction of salivary and bronchial secretions. • During cardiopulmonary resuscitation to treat sinus bradycardia or asystole. • For treatment of symptomatic sinus bradycardia induced by drugs or toxic substances such as pilocarpine, organophosphate pesticides, amanita muscaria mushrooms. • For management of bradycardia of acute myocardial infarction. • For prevention of cholinergic effects on the heart (e.g. arrhythmias, bradycardia) during surgery. • In combination with neostigmine during reversal of effect of non-depolarising muscle relaxants. Posology and method of administration Pre – operative medication. Adults: By the intravenous route: 300 - 600 micrograms immediately before induction of anaesthesia. By the intramuscular or subcutaneous route: 300 - 600 micrograms, one hour before induction of anaesthesia. Children: By the subcutaneous route 30 minutes before induction of anaesthesia Premature infants: 65 micrograms; Children up to 3kg: 100 micrograms; children 7-9kg:: 200 micrograms; Children 12-16kg: 300 micrograms; Children 20-27kg: 400 micrograms; Children 32kg: 500 micrograms; Children 41kg: 600 micrograms;
